Sickle cell anaemia is the hereditary form of anaemia that largely affects people of sub-Saharan African descent. This condition is caused by a mutation in the gene that tells the body to make haemoglobin, the red blood cell protein that carries oxygen throughout the body. In individuals with sickle cell anaemia, the abnormal haemoglobin causes red blood cells to become rigid and crescent-shaped, leading to blockages in blood vessels and a decrease in oxygen delivery to tissues.
People of sub-Saharan African descent are more likely to inherit the gene for sickle cell anaemia because it provides some protection against malaria. Malaria is a common and deadly disease in Africa, and individuals with the sickle cell trait are less likely to develop severe forms of the disease. As a result, the gene for sickle cell anaemia has been passed down through generations in populations where malaria is prevalent.
The symptoms of sickle cell anaemia can vary in severity and may include fatigue, pain, infections, and delayed growth. Treatment for sickle cell anaemia focuses on managing symptoms and preventing complications. This may include medications to reduce pain and inflammation, blood transfusions to increase haemoglobin levels, and bone marrow transplants in severe cases.
It is important for individuals of sub-Saharan African descent to be aware of their risk for sickle cell anaemia and to undergo genetic testing if they are planning to have children. Genetic counselling can help individuals understand their risk of passing the gene for sickle cell anaemia to their children and explore options for family planning.
For more information on sickle cell anaemia and its impact on people of sub-Saharan African descent, visit CDC - Sickle Cell Disease or NHLBI - Sickle Cell Disease.
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